CIP System Validation in Pharma: Protocol, Coverage, Parameters & Regulatory Expectations Validating CIP Systems in Pharma: Protocols, Parameters & Regulatory Compliance Clean-in-Place (CIP) systems are a cornerstone of modern pharmaceutical manufacturing. These automated cleaning systems eliminate manual intervention while ensuring equipment cleanliness, process consistency, and GMP compliance. However, to meet regulatory expectations, CIP systems must be rigorously validated using scientifically justified protocols. This article guides QA, QC, Engineering, and Validation teams through the full lifecycle of CIP system validation in alignment with FDA and EMA Annex 15 requirements. What Is CIP System Validation? CIP (Clean-in-Place) refers to the automated internal…