Swab Applicator & Detergent Compatibility Validation in Pharma How to Validate Swab Applicators and Detergent Compatibility in Cleaning Validation Introduction Swab sampling and cleaning agents are central components in pharmaceutical cleaning validation. The compatibility of swab applicators and detergents with the surfaces, residues, and analytical methods used must be validated to ensure accurate results. If left unchecked, interactions between swab material, detergent residues, and analytical systems (e.g., TOC, HPLC) can compromise recovery rates, interfere with quantification, or produce false positives. This guide explains a validated approach to swab applicator and detergent compatibility studies in compliance with FDA, EMA, and ICH…